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 External Resources

 12259https://www.addgene.org/12259  Addgene identifier (12259, reused)

 12260https://www.addgene.org/12260  Addgene identifier (12260, reused)

 96808https://www.addgene.org/96808  Addgene identifier (96808, reused)

 link.spr...-y.pdfhttps://link.springer.com/content/pdf/10.1186/s13024-025-00889-y.pdf  Article fulltext

 EMD‐52165https://www.ebi.ac.uk/pdbe/emdb/EMD‐52165  EMBL-EBI EMDB identifier (EMD‐52165)

 EMD‐52166https://www.ebi.ac.uk/pdbe/emdb/EMD‐52166  EMBL-EBI EMDB identifier (EMD‐52166)

 12518https://www.ebi.ac.uk/empiar/12518  EMBL-EBI EMPIAR identifier (EMPIAR‐12518)

 gro-2/151509http://resolver.sub.uni-goettingen.de/purl?gro-2/151509  GRO.publications identifier

 NM_000345.4https://www.ncbi.nlm.nih.gov/nuccore/NM_000345.4  NCBI nucleotide (NM_000345.4, reused)

 9606https://www.ncbi.nlm.nih.gov/nuccore/9606  NCBI taxonomy (human, Homo sapiens)

 1247190https://www.ncbi.nlm.nih.gov/nuccore/1247190  NCBI taxonomy (yeast, Saccharomyces cerevisiae BY4741)

 0000-0003-4640-2577https://orcid.org/0000-0003-4640-2577  ORCID identifier (Christof Brücke)

 0000-0003-2864-0854https://orcid.org/0000-0003-2864-0854  RCID identifier (Mohammed Al-Azzani)

 0000-0002-9459-3593https://orcid.org/0000-0002-9459-3593  ORCID identifier (Nagendran Ramalingam)

 0000-0001-7019-0186https://orcid.org/0000-0001-7019-0186  ORCID identifier (Rita L. Sousa)

 0009-0006-1755-1388https://orcid.org/0009-0006-1755-1388  ORCID identifier (Fiamma Buratti)

 0000-0001-8828-835Xhttps://orcid.org/0000-0001-8828-835X  ORCID identifier (Kevin Sicking)

 0000-0003-2843-628Xhttps://orcid.org/0000-0003-2843-628X  ORCID identifier (Leslie Amaral)

 0000-0003-2948-4187https://orcid.org/0000-0003-2948-4187  ORCID identifier (Ellen Gelpi)

 0009-0000-5229-4846https://orcid.org/0009-0000-5229-4846  ORCID identifier (Aishwarya Agarwal)

 0000-0002-6004-9872https://orcid.org/0000-0002-6004-9872  ORCID identifier (Susana Chaves)

 0000-0001-6676-0107https://orcid.org/0000-0001-6676-0107  ORCID identifier (Ulf Dettmer)

 0000-0001-7788-7074https://orcid.org/0000-0001-7788-7074  ORCID identifier (Janin Lautenschläger)

 0000-0002-2536-6581https://orcid.org/0000-0002-2536-6581  ORCID identifier (Markus Zweckstetter)

 0000-0002-8366-7622https://orcid.org/0000-0002-8366-7622  ORCID identifier (Ruben Fernandez-Busnadiego)

 0000-0002-1668-5177https://orcid.org/0000-0002-1668-5177  ORCID identifier (Alexander Zimprich)

 0000-0003-1679-1727https://orcid.org/0000-0003-1679-1727  ORCID identifier (Tiago Fleming Outeiro)

 459https://sfb1286.uni-goettingen.de/literature/publications/459  Published Data Registry entry (CRC 1286)

 1079https://prod.mbexc.uni-goettingen.de/literature/publications/1079  Published Data Registry entry (MBExC, preprint)

 9HGShttps://www.rcsb.org/structure/9HGS  RCSB PDB Identifier (DOI:10.2210/pdb9HGS/pdb)

 9HGRhttps://www.rcsb.org/structure/9HGR  RCSB PDB Identifier (DOI:10.2210/pdb9HGR/pdb)

 6RT0https://www.rcsb.org/structure/6RT0  RCSB PDB Identifier (DOI:10.2210/pdb6RT0/pdb, reused)

 8BQWhttps://www.rcsb.org/structure/8BQW  RCSB PDB Identifier (DOI:10.2210/pdb8BQW/pdb, reused)

 03zj4c476https://ror.org/03zj4c476  ROR identifier (03zj4c476, Aligning Science Across Parkinson's)

 04b6nzv94https://ror.org/04b6nzv94  ROR identifier (04b6nzv94, Brigham and Women's Hospital)

 043j0f473https://ror.org/043j0f473  ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)

 03vek6s52https://ror.org/03vek6s52  ROR identifier (03vek6s52, Harvard University)

 00cfam450https://ror.org/00cfam450  ROR identifier (00cfam450, Helmholtz Zentrum München)

 05n3x4p02https://ror.org/05n3x4p02  ROR identifier (05n3x4p02, Medical University of Vienna)

 03av75f26https://ror.org/03av75f26  ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)

 05xy1nn52https://ror.org/05xy1nn52  ROR identifier (05xy1nn52, Multiscale Bioimaging)

 02tphfq59https://ror.org/02tphfq59  ROR identifier (02tphfq59, National University of Rosario)

 01kj2bm70https://ror.org/01kj2bm70  ROR identifier (01kj2bm70, Newcastle University)

 02kkvpp62https://ror.org/02kkvpp62  ROR identifier (02kkvpp62, Technical University of Munich)

 021ft0n22https://ror.org/021ft0n22  ROR identifier (021ft0n22, University Medical Center Göttingen)

 013meh722https://ror.org/013meh722  ROR identifier (013meh722, University of Cambridge)

 01y9bpm73https://ror.org/01y9bpm73  ROR identifier (01y9bpm73, University of Göttingen)

 037wpkx04https://ror.org/037wpkx04  ROR identifier (037wpkx04, University of Minho)

 03prydq77https://ror.org/03prydq77  ROR identifier (03prydq77, University of Vienna)

 CVCL_0063https://scicrunch.org/resolver/CVCL_0063  SciCrunch identifier (RRID:CVCL_0063, HEK293T)

 CVCL_0030https://scicrunch.org/resolver/CVCL_0030  SciCrunch identifier (RRID:CVCL_0030, HeLa)

 SCR_026330https://scicrunch.org/resolver/SCR_026330  SciCrunch identifier (RRID:SCR_026330, BMG Labtech: CLARIOstar Plus)

 SCR_028510https://scicrunch.org/resolver/SCR_028510  SciCrunch identifier (RRID:SCR_028510, Bruker: Avance III HD Ascend 700 MHz NMR Spectrometer)

 SCR_014222https://scicrunch.org/resolver/SCR_014222  SciCrunch identifier (RRID:SCR_014222, Coot)

 SCR_018392https://scicrunch.org/resolver/SCR_018392  SciCrunch identifier (RRID:SCR_018392, crYOLO)

 SCR_016732https://scicrunch.org/resolver/SCR_016732  SciCrunch identifier (RRID:SCR_016732, CTFFIND)

 SCR_002285https://scicrunch.org/resolver/SCR_002285  SciCrunch identifier (RRID:SCR_002285, Fiji)

 SCR_002798https://scicrunch.org/resolver/SCR_002798  SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

 SCR_016387https://scicrunch.org/resolver/SCR_016387  SciCrunch identifier (RRID:SCR_016387, Illumina NovaSeq 6000 Sequencing System)

 SCR_016137https://scicrunch.org/resolver/SCR_016137  SciCrunch identifier (RRID:SCR_016137, Microsoft Excel)

 SCR_016499https://scicrunch.org/resolver/SCR_016499  SciCrunch identifier (RRID:SCR_016499, MotionCor2)

 SCR_014224https://scicrunch.org/resolver/SCR_014224  SciCrunch identifier (RRID:SCR_014224, Phenix)

 SCR_016274https://scicrunch.org/resolver/SCR_016274  SciCrunch identifier (RRID:SCR_016274, RELION)

 SCR_014228https://scicrunch.org/resolver/SCR_014228  SciCrunch identifier (RRID:SCR_014228, Sparky)

 SCR_025773https://scicrunch.org/resolver/SCR_025773  SciCrunch identifier (RRID:SCR_025773, Thermo Fisher: Vitrobot Mark IV system)

 SCR_014227https://scicrunch.org/resolver/SCR_014227  SciCrunch identifier (RRID:SCR_014227, TopSpin)

 SCR_021351https://scicrunch.org/resolver/SCR_021351  SciCrunch identifier (RRID:SCR_021351, Zeiss Axio Observer)

 SCR_020922https://scicrunch.org/resolver/SCR_020922  SciCrunch identifier (RRID:SCR_020922, Zeiss LSM 780 Confocal Laser Scanning Microscope)

 SCR_013672https://scicrunch.org/resolver/SCR_013672  SciCrunch identifier (RRID:SCR_013672, ZEN Digital Imaging for Light Microscopy)

 static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1186%2Fs13024-025-00889-y/MediaObjects/13024_2025_889_MOESM1_ESM.pdf  Supplemental material

 protocol...lpk/v1https://www.protocols.io/view/single-particle-analysis-of-synuclein-fibrils-81wgbxozylpk/v1  Supplemental material (protocol)

 mbexc.de...tures/https://mbexc.de/de/a-novel-alpha-synuclein-g14r-missense-variant-is-associated-with-atypical-neuropathological-features/  Website entry (mbexc.de)