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 External Resources

 nature.c...-1.pdfhttps://www.nature.com/articles/s41467-021-24741-1.pdf  Article fulltext

 EMD-12994https://www.ebi.ac.uk/pdbe/emdb/EMD-12994  EMBL-EBI EMDB identifier (EMD-12994)

 gro-2/89042http://resolver.sub.uni-goettingen.de/purl?gro-2/89042  GRO.publications identifier

 0000-0002-4488-1386https://orcid.org/0000-0002-4488-1386  ORCID identifier (Melissa Jurica)

 7B9Chttps://www.rcsb.org/structure/7B9C  RCSB PDB Identifier (7B9C)

 7B0Ihttps://www.rcsb.org/structure/7B0I  RCSB PDB Identifier (7B0I)

 7B91https://www.rcsb.org/structure/7B91  RCSB PDB Identifier (7B91)

 7B92https://www.rcsb.org/structure/7B92  RCSB PDB Identifier (7B92)

 7OMFhttps://www.rcsb.org/structure/7OMF  RCSB PDB Identifier (7OMF)

 7OPIhttps://www.rcsb.org/structure/7OPI  RCSB PDB Identifier (7OPI)

 7ONBhttps://www.rcsb.org/structure/7ONB  RCSB PDB Identifier (7ONB)

 1/367https://mbexc.uni-goettingen.de/archive/1/367  Research Data Archive (supplemental material)

 043jzw605https://ror.org/043jzw605  ROR identifier (043jzw605, Institute of Cancer Research)

 05xy1nn52https://ror.org/05xy1nn52  ROR identifier (05xy1nn52, Multiscale Bioimaging)

 02dqehb95https://ror.org/02dqehb95  ROR identifier (02dqehb95, Purdue University West Lafayette)

 021ft0n22https://ror.org/021ft0n22  ROR identifier (021ft0n22, University Medical Center Göttingen)

 03s65by71https://ror.org/03s65by71  ROR identifier (03s65by71, University of California, Santa Cruz)

 CVCL_0291https://scicrunch.org/resolver/CVCL_0291  SciCrunch identifier (RRID:CVCL_0291, HCT116)

 CVCL_0030https://scicrunch.org/resolver/CVCL_0030  SciCrunch identifier (RRID:CVCL_0030, HeLa)

 SCR_015747https://scicrunch.org/resolver/SCR_015747  SciCrunch identifier (RRID:SCR_015747, AIMLESS)

 SCR_010876https://scicrunch.org/resolver/SCR_010876  SciCrunch identifier (RRID:SCR_010876, Arpeggio)

 SCR_002959https://scicrunch.org/resolver/SCR_002959  SciCrunch identifier (RRID:SCR_002959, Chimera)

 SCR_014222https://scicrunch.org/resolver/SCR_014222  SciCrunch identifier (RRID:SCR_014222, Coot)

 SCR_016501https://scicrunch.org/resolver/SCR_016501  SciCrunch identifier (RRID:SCR_016501, cryoSPARC)

 SCR_002798https://scicrunch.org/resolver/SCR_002798  SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

 SCR_014219https://scicrunch.org/resolver/SCR_014219  SciCrunch identifier (RRID:SCR_014219, Phaser)

 SCR_016736https://scicrunch.org/resolver/SCR_016736  SciCrunch identifier (RRID:SCR_016736, Phenix.refine)

 SCR_000305https://scicrunch.org/resolver/SCR_000305  SciCrunch identifier (RRID:SCR_000305, PyMOL)

 SCR_016274https://scicrunch.org/resolver/SCR_016274  SciCrunch identifier (RRID:SCR_016274, RELION)

 SCR_017293https://scicrunch.org/resolver/SCR_017293  SciCrunch identifier (RRID:SCR_017293, SerialEM)

 SCR_014593https://scicrunch.org/resolver/SCR_014593  SciCrunch identifier (RRID:SCR_014593, Thermo Xcalibur)

 SCR_018071https://scicrunch.org/resolver/SCR_018071  SciCrunch identifier (RRID:SCR_018071, Warp)

 SCR_015652https://scicrunch.org/resolver/SCR_015652  SciCrunch identifier (RRID:SCR_015652, XDS Program Package)

 static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-24741-1/MediaObjects/41467_2021_24741_MOESM1_ESM.pdf  Supplemental material

 goeseek.gwdguser.de/studies/136https://goeseek.gwdguser.de/studies/136  Supplemental material (goeseek study)

 static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-24741-1/MediaObjects/41467_2021_24741_MOESM3_ESM.pdf  Supplemental material (reporting summary)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-24741-1/MediaObjects/41467_2021_24741_MOESM4_ESM.xlsx  Supplemental material (source data)

 static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-24741-1/MediaObjects/41467_2021_24741_MOESM2_ESM.xlsx  Supplemental material (table)

 Q112581301https://www.wikidata.org/wiki/Q112581301  Wikidata ID