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Publication

Property	Value
Working Groups	RG Fischer, RG Gärtner, RG Rehling, RG Stadelmann-Nessler
Subproject	RA1.2, RA2.2
Open Access	Yes
Publication Type	Journal Article
Peer Reviewed	Yes
PMID	34764281
DOI	10.1038/s41467-021-26880-x
Publication Year	2021
Title	Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy
Journal	Nature Communications
ISSN	2041-1723
eISSN	2041-1723
URL	http://dx.doi.org/10.1038/s41467-021-26880-x
Issue	1
Volume	12
Journal Abbreviation	Nat Commun
Authors	Kettwig M, Ternka K, Wendland K, Krüger DM, Zampar S, Schob C, Franz J, Aich A, Winkler A, Sakib MS, Kaurani L, Epple R, Werner HB, Hakroush S, Kitz J, Prinz M, Bartok E, Hartmann G, Schröder S, Rehling P, Henneke M, Boretius S, Alia A, Wirths O, Fischer A, Stadelmann C, Nessler S, Gärtner J
First Author	Kettwig M
Last Author	Gärtner J
Scholia	Wikidata-based representation at Scholia

External Resources

nature.c...-x.pdfhttps://www.nature.com/articles/s41467-021-26880-x.pdf Article fulltext

gro-2/94539http://resolver.sub.uni-goettingen.de/purl?gro-2/94539 GRO.publications identifier

GCA_000001635.26https://www.ncbi.nlm.nih.gov/assembly/GCA_000001635.26 NCBI assembly (GCA_000001635.26, reused)

GCA_000001635.26https://www.ncbi.nlm.nih.gov/datasets/genome/GCA_000001635.26 NCBI genome identifier (GCA_000001635.26, reused)

GSE180138https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE180138 NCBI GEO Dataset (GSE180138)

NM_026611.2https://www.ncbi.nlm.nih.gov/nuccore/NM_026611.2 NCBI nucleotide (NM_026611.2, reused)

NM_001083938.3https://www.ncbi.nlm.nih.gov/nuccore/NM_001083938.3 NCBI nucleotide (NM_001083938.3, reused)

10090https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 NCBI taxonomy (mouse, Mus musculus)

0000-0003-4804-7716https://orcid.org/0000-0003-4804-7716 ORCID identifier (Matthias Kettwig)

0000-0003-3773-4625https://orcid.org/0000-0003-3773-4625 ORCID identifier (Katharina Ternka)

0000-0003-1950-9547https://orcid.org/0000-0003-1950-9547 ORCID identifier (Dennis M. Krüger)

0000-0003-0134-0974https://orcid.org/0000-0003-0134-0974 ORCID identifier (Silvia Zampar)

0000-0001-7523-6622https://orcid.org/0000-0001-7523-6622 ORCID identifier (Jonas Franz)

0000-0001-8331-9874https://orcid.org/0000-0001-8331-9874 ORCID identifier (Abhishek Aich)

0000-0002-0903-9791https://orcid.org/0000-0002-0903-9791 ORCID identifier (M. Sadman Sakib)

0000-0002-2304-6111https://orcid.org/0000-0002-2304-6111 ORCID identifier (Lalit Kaurani)

0000-0002-7710-5738https://orcid.org/0000-0002-7710-5738 ORCID identifier (Hauke B. Werner)

0000-0002-0349-1955https://orcid.org/0000-0002-0349-1955 ORCID identifier (Marco Prinz)

0000-0003-0556-1950https://orcid.org/0000-0003-0556-1950 ORCID identifier (Eva Bartok)

0000-0001-5661-5272https://orcid.org/0000-0001-5661-5272 ORCID identifier (Peter Rehling)

0000-0003-2792-7423https://orcid.org/0000-0003-2792-7423 ORCID identifier (Susann Boretius)

0000-0002-4115-0334https://orcid.org/0000-0002-4115-0334 ORCID identifier (Oliver Wirths)

0000-0001-8546-1161https://orcid.org/0000-0001-8546-1161 ORCID identifier (André Fischer)

0000-0003-1766-5458https://orcid.org/0000-0003-1766-5458 ORCID identifier (Christine Stadelmann-Nessler)

0000-0003-4108-7109https://orcid.org/0000-0003-4108-7109 ORCID identifier (Jutta Gärtner)

48https://rdp.sfb274.de/literature/publications/48 Published Data Registry entry (TRR274)

141https://sfb1286.uni-goettingen.de/literature/publications/141 Published Data Registry entry (CRC 1286)

1/347https://mbexc.uni-goettingen.de/archive/1/347 Research Data Archive (supplemental material)

043j0f473https://ror.org/043j0f473 ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)

02f99v835https://ror.org/02f99v835 ROR identifier (02f99v835, German Primate Center)

03xq4x896https://ror.org/03xq4x896 ROR identifier (03xq4x896, Instituut voor Tropische Geneeskunde)

027bh9e22https://ror.org/027bh9e22 ROR identifier (027bh9e22, Leiden University)

03s7gtk40https://ror.org/03s7gtk40 ROR identifier (03s7gtk40, Leipzig University)

04a7f6w43https://ror.org/04a7f6w43 ROR identifier (04a7f6w43, Max Planck Institute of Experimental Medicine)

05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)

021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)

041nas322https://ror.org/041nas322 ROR identifier (041nas322, University of Bonn)

01y9bpm73https://ror.org/01y9bpm73 ROR identifier (01y9bpm73, University of Göttingen)

0245cg223https://ror.org/0245cg223 ROR identifier (0245cg223, University of Freiburg)

SCR_007353https://scicrunch.org/resolver/SCR_007353 SciCrunch identifier (RRID:SCR_007353, Advanced 3D Visualization and Volume Modeling)

SCR_014289https://scicrunch.org/resolver/SCR_014289 SciCrunch identifier (RRID:SCR_014289, ANY-maze)

SCR_001456https://scicrunch.org/resolver/SCR_001456 SciCrunch identifier (RRID:SCR_001456, BD FACSDiva)

SCR_017344https://scicrunch.org/resolver/SCR_017344 SciCrunch identifier (RRID:SCR_017344, Cell Ranger)

SCR_008520https://scicrunch.org/resolver/SCR_008520 SciCrunch identifier (RRID:SCR_008520, FlowJo)

SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

SCR_014246https://scicrunch.org/resolver/SCR_014246 SciCrunch identifier (RRID:SCR_014246, ImageQuant)

SCR_014212https://scicrunch.org/resolver/SCR_014212 SciCrunch identifier (RRID:SCR_014212, Origin)

SCR_001964https://scicrunch.org/resolver/SCR_001964 SciCrunch identifier (RRID:SCR_001964, ParaVision)

SCR_008394https://scicrunch.org/resolver/SCR_008394 SciCrunch identifier (RRID:SCR_008394, Python)

SCR_018139https://scicrunch.org/resolver/SCR_018139 SciCrunch identifier (RRID:SCR_018139, scanpy)

SCR_019213https://scicrunch.org/resolver/SCR_019213 SciCrunch identifier (RRID:SCR_019213, ShinyGO)

SCR_014227https://scicrunch.org/resolver/SCR_014227 SciCrunch identifier (RRID:SCR_014227, TopSpin)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-26880-x/MediaObjects/41467_2021_26880_MOESM1_ESM.pdf Supplemental material

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-26880-x/MediaObjects/41467_2021_26880_MOESM3_ESM.pdf Supplemental material

goeseek.gwdguser.de/studies/125https://goeseek.gwdguser.de/studies/125 Supplemental material (goeseek study)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-26880-x/MediaObjects/41467_2021_26880_MOESM2_ESM.pdf Supplemental material (peer review)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-26880-x/MediaObjects/41467_2021_26880_MOESM5_ESM.pdf Supplemental material (reporting summary)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-26880-x/MediaObjects/41467_2021_26880_MOESM6_ESM.xlsx Supplemental material (source data)

static-c...M.xlsxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41467-021-26880-x/MediaObjects/41467_2021_26880_MOESM4_ESM.xlsx Supplemental material (table)

mbexc.de...pathy/https://mbexc.de/interferon-driven-brain-phenotype-in-a-mouse-model-of-rnaset2-deficient-leukoencephalopathy/ Website entry (mbexc.de)

Q112303892https://www.wikidata.org/wiki/Q112303892 Wikidata ID

Linked Antibodies

PID	Type	Antigen symbol	Antibody Registry ID	Name
primary-0587	primary	MBP	AB_305869	Anti-Myelin Basic Protein antibody
primary-0715	primary	GFAP	AB_2232308	GFAP antibody
primary-0845	primary	ITGA2B	AB_2732852	Recombinant Anti-CD41 antibody [EPR4330]
primary-0846	primary	CD3		Anti-CD3 Antibody
primary-0847	primary	AIF1	AB_10917271	Anti-Iba1/AIF1 Antibody
primary-0848	primary	RBFOX3	AB_2532109	Recombinant Anti-NeuN antibody [EPR12763] - Neuronal Marker
primary-0849	primary	TMEM119	AB_2800343	Recombinant Anti-TMEM119 antibody [28-3] - Microglial marker
primary-0850	primary	PECAM1	AB_2631039	Anti-CD31 antibody
primary-0851	primary	CD8A	AB_2864935	CD8a Monoclonal Antibody (4SM15)

Technical Support: menoci@medizin.uni-goettingen.de

Department of Medical Informatics
University Medical Center Göttingen
Imprint

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External Resources

Linked Antibodies

Technical support

Links

Spokesperson

Prof. Dr. Tobias Moser

Spokesperson of Cluster of Excellence