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Publication

Property	Value
Working Groups	RG Bähr, RG Möbius
Subproject	None
Open Access	Yes
Publication Type	Journal Article
Peer Reviewed	Yes
PMID	38890531
DOI	10.1038/s41591-024-02937-4
Publication Year	2024
Title	Plasma extracellular vesicle tau and TDP-43 as diagnostic biomarkers in FTD and ALS
Journal	Nature Medicine
ISSN	1078-8956
eISSN	1546-170X
URL	http://dx.doi.org/10.1038/s41591-024-02937-4
Pages	1771-1783
Issue	6
Volume	30
Journal Abbreviation	Nat Med
Authors	Chatterjee M, Özdemir S, Fritz C, Möbius W, Kleineidam L, Mandelkow E, Biernat J, Doğdu C, Peters O, Cosma NC, Wang X, Schneider LS, Priller J, Spruth E, Kühn AA, Krause P, Klockgether T, Vogt IR, Kimmich O, Spottke A, Hoffmann DC, Fliessbach K, Miklitz C, McCormick C, Weydt P, Falkenburger B, Brandt M, Guenther R, Dinter E, Wiltfang J, Hansen N, Bähr M, Zerr I, Flöel A, Nestor PJ, Düzel E, Glanz W, Incesoy E, Bürger K, Janowitz D, Perneczky R, Rauchmann BS, Hopfner F, Wagemann O, Levin J, Teipel S, Kilimann I, Goerss D, Prudlo J, Gasser T, Brockmann K, Mengel D, Zimmermann M, Synofzik M, Wilke C, Selma-González J, Turon-Sans J, Santos-Santos MA, Alcolea D, Rubio-Guerra S, Fortea J, Carbayo Á, Lleó A, Rojas-García R, Illán-Gala I, Wagner M, Frommann I, Roeske S, Bertram L, Heneka MT, Brosseron F, Ramirez A, Schmid M, Beschorner R, Halle A, Herms J, Neumann M, Barthélemy NR, Bateman RJ, Rizzu P, Heutink P, Dols-Icardo O, Höglinger G, Hermann A, Schneider A
First Author	Chatterjee M
Last Author	Schneider A

External Resources

nature.c...-4.pdfhttps://www.nature.com/articles/s41591-024-02937-4.pdf Article fulltext

gro-2/143829http://resolver.sub.uni-goettingen.de/purl?gro-2/143829 GRO.publications identifier

9606https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 NCBI taxonomy (human, Homo sapiens)

0000-0002-2902-7165https://orcid.org/0000-0002-2902-7165 ORCID identifier (Wiebke Möbius)

0000-0003-4655-4829https://orcid.org/0000-0003-4655-4829 ORCID identifier (Eckhard Mandelkow)

0000-0002-2656-8046https://orcid.org/0000-0002-2656-8046 ORCID identifier (Nicoleta Carmen Cosma)

0000-0001-7596-0979https://orcid.org/0000-0001-7596-0979 ORCID identifier (Josef Priller)

0000-0002-4134-9060https://orcid.org/0000-0002-4134-9060 ORCID identifier (Andrea A. Kühn)

0000-0003-1492-5330https://orcid.org/0000-0003-1492-5330 ORCID identifier (Jens Wiltfang)

0000-0002-9570-1592https://orcid.org/0000-0002-9570-1592 ORCID identifier (Mathias Bähr)

0000-0002-7515-8596https://orcid.org/0000-0002-7515-8596 ORCID identifier (Kathrin Brockmann)

0000-0002-3819-3245https://orcid.org/0000-0002-3819-3245 ORCID identifier (Daniel Alcolea)

0000-0001-7652-8029https://orcid.org/0000-0001-7652-8029 ORCID identifier (Sara Rubio-Guerra)

0000-0002-1340-638Xhttps://orcid.org/0000-0002-1340-638X ORCID identifier (Juan Fortea)

0000-0001-9282-8603https://orcid.org/0000-0001-9282-8603 ORCID identifier (Álvaro Carbayo)

0000-0002-2568-5478https://orcid.org/0000-0002-2568-5478 ORCID identifier (Alberto Lleó)

0000-0002-7244-2014https://orcid.org/0000-0002-7244-2014 ORCID identifier (Ingo Frommann)

0000-0002-8262-4356https://orcid.org/0000-0002-8262-4356 ORCID identifier (Sandra Roeske)

0009-0005-3594-6925https://orcid.org/0009-0005-3594-6925 ORCID identifier (Lucas Bertram)

0000-0003-4996-1630https://orcid.org/0000-0003-4996-1630 ORCID identifier (Michael Thomas Heneka)

0000-0003-4991-763Xhttps://orcid.org/0000-0003-4991-763X ORCID identifier (Alfredo Ramirez)

0000-0003-1109-915Xhttps://orcid.org/0000-0003-1109-915X ORCID identifier (Rudi Beschorner)

0000-0002-7729-1702https://orcid.org/0000-0002-7729-1702 ORCID identifier (Randall J. Bateman)

0000-0001-5218-1737https://orcid.org/0000-0001-5218-1737 ORCID identifier (Peter Heutink)

0000-0003-2656-8748https://orcid.org/0000-0003-2656-8748 ORCID identifier (Oriol Dols-Icardo)

0000-0001-7587-6187https://orcid.org/0000-0001-7587-6187 ORCID identifier (Günter U. Höglinger)

0000-0002-7364-7791https://orcid.org/0000-0002-7364-7791 ORCID identifier (Andreas Hermann)

0000-0001-9540-8700https://orcid.org/0000-0001-9540-8700 ORCID identifier (Anja Schneider)

1/465https://mbexc.uni-goettingen.de/archive/1/465 Research Data Archive (supplemental material)

03je5c526https://ror.org/03je5c526 ROR identifier (03je5c526, Atatürk University)

00zca7903https://ror.org/00zca7903 ROR identifier (00zca7903, Biomedical Research Networking Center on Neurodegenerative Diseases)

01ygm5w19https://ror.org/01ygm5w19 ROR identifier (01ygm5w19, Centre for Biomedical Network Research on Rare Diseases)

001w7jn25https://ror.org/001w7jn25 ROR identifier (001w7jn25, Charité - Universitätsmedizin Berlin)

04c4bwh63https://ror.org/04c4bwh63 ROR identifier (04c4bwh63, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases)

043j0f473https://ror.org/043j0f473 ROR identifier (043j0f473, German Center for Neurodegenerative Diseases)

059n1d175https://ror.org/059n1d175 ROR identifier (059n1d175, Hospital de Sant Pau)

01hcx6992https://ror.org/01hcx6992 ROR identifier (01hcx6992, Humboldt-Universität zu Berlin)

041kmwe10https://ror.org/041kmwe10 ROR identifier (041kmwe10, Imperial College London)

02jet3w32https://ror.org/02jet3w32 ROR identifier (02jet3w32, Klinikum der Universität München)

03av75f26https://ror.org/03av75f26 ROR identifier (03av75f26, Max Planck Institute for Multidisciplinary Sciences)

05xy1nn52https://ror.org/05xy1nn52 ROR identifier (05xy1nn52, Multiscale Bioimaging)

025z3z560https://ror.org/025z3z560 ROR identifier (025z3z560, Munich Cluster for Systems Neurology)

02wkzzr31https://ror.org/02wkzzr31 ROR identifier (02wkzzr31, Nanoscale Microscopy and Molecular Physiology of the Brain)

00ggpsq73https://ror.org/00ggpsq73 ROR identifier (00ggpsq73, Otto-von-Guericke University Magdeburg)

02kkvpp62https://ror.org/02kkvpp62 ROR identifier (02kkvpp62, Technical University of Munich)

052g8jq94https://ror.org/052g8jq94 ROR identifier (052g8jq94, Universitat Autònoma de Barcelona)

04dm1cm79https://ror.org/04dm1cm79 ROR identifier (04dm1cm79, Universitätsmedizin Rostock)

02jx3x895https://ror.org/02jx3x895 ROR identifier (02jx3x895, University College London)

01xnwqx93https://ror.org/01xnwqx93 ROR identifier (01xnwqx93, University Hospital Bonn)

04za5zm41https://ror.org/04za5zm41 ROR identifier (04za5zm41, University Hospital Carl Gustav Carus)

03m04df46https://ror.org/03m04df46 ROR identifier (03m04df46, University Hospital Magdeburg)

021ft0n22https://ror.org/021ft0n22 ROR identifier (021ft0n22, University Medical Center Göttingen)

00nt41z93https://ror.org/00nt41z93 ROR identifier (00nt41z93, University of Aveiro)

041nas322https://ror.org/041nas322 ROR identifier (041nas322, University of Bonn)

00rcxh774https://ror.org/00rcxh774 ROR identifier (00rcxh774, University of Cologne)

01nrxwf90https://ror.org/01nrxwf90 ROR identifier (01nrxwf90, University of Edinburgh)

00r1edq15https://ror.org/00r1edq15 ROR identifier (00r1edq15, University of Greifswald)

036x5ad56https://ror.org/036x5ad56 ROR identifier (036x5ad56, University of Luxembourg)

0464eyp60https://ror.org/0464eyp60 ROR identifier (0464eyp60, University of Massachusetts Chan Medical School)

00rqy9422https://ror.org/00rqy9422 ROR identifier (00rqy9422, University of Queensland)

05krs5044https://ror.org/05krs5044 ROR identifier (05krs5044, University of Sheffield)

03a1kwz48https://ror.org/03a1kwz48 ROR identifier (03a1kwz48, University of Tübingen)

036c27j91https://ror.org/036c27j91 ROR identifier (036c27j91, Washington University Medical Center)

CVCL_0019https://scicrunch.org/resolver/CVCL_0019 SciCrunch identifier (RRID:CVCL_0019, SH-SY5Y)

SCR_002798https://scicrunch.org/resolver/SCR_002798 SciCrunch identifier (RRID:SCR_002798, GraphPad Prism)

SCR_019096https://scicrunch.org/resolver/SCR_019096 SciCrunch identifier (RRID:SCR_019096, IBM SPSS Statistics)

SCR_015044https://scicrunch.org/resolver/SCR_015044 SciCrunch identifier (RRID:SCR_015044, MedCalc)

SCR_001905https://scicrunch.org/resolver/SCR_001905 SciCrunch identifier (RRID:SCR_001905, R Project for Statistical Computing)

SCR_000432https://scicrunch.org/resolver/SCR_000432 SciCrunch identifier (RRID:SCR_000432, RStudio)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41591-024-02937-4/MediaObjects/41591_2024_2937_MOESM1_ESM.pdf Supplemental material (figure)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41591-024-02937-4/MediaObjects/41591_2024_2937_MOESM2_ESM.pdf Supplemental material (reporting summary)

static-c...SM.pdfhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41591-024-02937-4/MediaObjects/41591_2024_2937_MOESM3_ESM.pdf Supplemental material (table)

static-c...M.docxhttps://static-content.springer.com/esm/art%3A10.1038%2Fs41591-024-02937-4/MediaObjects/41591_2024_2937_MOESM4_ESM.docx Supplemental material (table)

mbexc.de...d-als/https://mbexc.de/plasma-extracellular-vesicle-tau-and-tdp-43-as-diagnostic-biomarkers-in-ftd-and-als/ Website entry (mbexc.de)

Linked Antibodies

PID	Type	Antigen symbol	Antibody Registry ID	Name
primary-0185	primary	MAPT	AB_223647	Phospho-Tau (Ser202, Thr205) Monoclonal Antibody
primary-0577	primary	FLOT2	AB_397767	Purified Mouse Anti-Flotillin-2
primary-0579	primary	CANX	AB_476845	Anti-Calnexin antibody
primary-1447	primary	LIN-28A	AB_2234537	Human LIN-28A Antibody
primary-1542	primary	SYUA	AB_1609536	alpha Synuclein (SNCA) Mouse Monoclonal Antibody
primary-1543	primary		AB_662812	Purified anti-β-Amyloid, 17-24 Antibody
primary-1544	primary	MAPT	AB_11212693	Anti-Tau (3-repeat isoform RD3) Antibody, clone 8E6/C11
primary-1545	primary		AB_3068614	Anti-4R Tau antibody [EPR21725]
primary-1546	primary	TDP43		HRP Anti-TDP43 antibody [EPR5810]
primary-1547	primary	CD171	AB_2043813	CD171 Monoclonal Antibody (eBio5G3 (5G3)), Biotin, eBioscience™
primary-1548	primary		AB_470090	Mouse IgG2a kappa Isotype Control (eBM2a), Biotin, eBioscience™
secondary-0799	secondary		AB_2617138	Goat Anti-Rabbit Immunoglobulins/HRP antibody
secondary-0938	secondary		AB_2617137	Goat Anti-Mouse Immunoglobulins/HRP